Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/554
Título: Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
Autor: Moreno, Virtudes
Lorenzo, Júlia
Aviles, Francesc X.
Garcia, M. Helena
Ribeiro, João P.
Morais, Tânia S.
Florindo, Pedro
Robalo, M. Paula
Palavras-chave: Cancer- cell-growth
Structural-characterization
Organometallic chemistry
Anticancer activity
Arene complexes
Agents
Derivatives
Inhibition
Apoptosis
Assay
Data: 2010
Editora: HINDAWI PUBLISHING CORPORATION
Citação: Moreno V, Lorenzo J, Aviles F X, Garcia M H, Ribeiro J P, Morais T S, Florindo P, Robalo M P.Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands. Bioinorganic Chemistry and Applications. 2010: Art. No. 936834.
Relatório da Série N.º: ;936834
Resumo: Four cationic ruthenium(II) complexes with the formula [Ru(eta(5)-C5H5)(PPh3)(2)](+), with L = 5-phenyl-1H-tetrazole (TzH) 1, imidazole (ImH) 2, benzo[1,2-b; 4,3-b'] dithio-phen-2-carbonitrile (Bzt) 3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt) 4 were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).
Peer review: yes
URI: http://hdl.handle.net/10400.21/554
ISSN: 1565-3633
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos



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