Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/5408
Título: Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review
Autor: Caetano, Liliana Aranha
Almeida, António José
Gonçalves, Lídia Maria Diogo
Palavras-chave: Mucosal immunity
Microparticles
Nanoparticles
Tuberculosis
Vaccination
Vaccine delivery systems
Immunity
Data: Set-2014
Editora: American Scientific Publishers
Citação: Caetano LA, Almeida AJ, Gonçalves LM. Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review. J Biomed Nanotechnol. 2014;10(9):2295-316.
Resumo: Next-generation vaccines for tuberculosis should be designed to prevent the infection and to achieve sterile eradication of Mycobacterium tuberculosis. Mucosal vaccination is a needle-free vaccine strategy that provides protective immunity against pathogenic bacteria and viruses in both mucosal and systemic compartments, being a promising alternative to current tuberculosis vaccines. Micro and nanoparticles have shown great potential as delivery systems for mucosal vaccines. In this review, the immunological principles underlying mucosal vaccine development will be discussed, and the application of mucosal adjuvants and delivery systems to the enhancement of protective immune responses at mucosal surfaces will be reviewed, in particular those envisioned for oral and nasal routes of administration. An overview of the essential vaccine candidates for tuberculosis in clinical trials will be provided, with special emphasis on the potential different antigens and immunization regimens.
Peer review: yes
URI: http://hdl.handle.net/10400.21/5408
DOI: 10.1166/jbn.2014.1984
Versão do Editor: http://www.ingentaconnect.com/content/asp/jbn/2014/00000010/00000009/art00026
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