Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/5127
Título: Synthesis of organometallic Ruthenium(II) complexes with strong activity against several human canceer cell lines
Autor: Morais, Tânia S.
Silva, Tiago J. L.
Marques, Fernanda
Robalo, Maria Paula
Avecilla, Fernando
Madeira, Paulo J. Amorim
Mendes, Paulo J. G.
Santos, Isabel
Helena Garcia, M.
Palavras-chave: Ruthenium(II)
Cyclopentadienyl
Heteroaromatic ligand
Organometallic
Effective core potentials
Cyclopentadiennyl derivative complexes
Molecular calculations
Heteroaromatic ligands
Anticancer agents
Inhibition
Growth
Cytotoxicity
Chemistry
Elements
Data: Set-2012
Editora: Elsevier Science INC
Resumo: A new family of "RuCp" (Cp=eta(5)-C5H5) derivatives with bidentate N,O and N,N'-heteroaromatic ligands revealed outstanding cytotoxic properties against several human cell lines namely, A2780, A2780CisR, HT29, MCF7, MDAMB231, and PD. IC50 values were much lower than those found for cisplatin. Crystal structure of compound 4 was determined by X-ray diffraction studies. Density functional theory (DFT) calculations performed for compound 1 showed electronic flow from the ruthenium center to the coordinated bidentate ligand, in agreement with the electrochemical studies and the existence of a metal-to-ligand charge-transfer (MLCT) band evidenced by spectroscopic data.
Peer review: yes
URI: http://hdl.handle.net/10400.21/5127
DOI: 10.1016/j.jinorgbio.2012.04.014
ISSN: 0162-0134
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos



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