Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/5055
Título: Micronutrients intake associated with DNA damage assessed by in a human biomonitoring study
Autor: Ladeira, Carina
Viegas, Susana
Carolino, Elisabete
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Comet assay
DNA damage
Micronutrients
Human biomonitoring
Oxidative damage
Data: Set-2015
Citação: Ladeira C, Viegas S, Carolino E, Gomes MC, Brito M. Micronutrients intake associated with DNA damage assessed by in a human biomonitoring study. In ICAW 2015 – 11th International Comet Assay Workshop, Antwerpen, Belgium, 1st to 4th September 2015.
Resumo: Nutrition science has evolved into a multidisciplinary field that applies molecular biology and integrates individual health with the epidemiologic investigation of population health. Nutritional genomics studies the functional interaction of food and its components, macro and micronutrients, with the genome at the molecular, cellular, and systemic level. Diet can influence cancer development in several ways, namely direct action of carcinogens in food that can damage DNA, diet components (macro or micronutrients) that can block or induce enzymes involved in activation or deactivation of carcinogenic substances. Moreover, inadequate intake of some molecules involved in DNA synthesis, repair or methylation can influence mutation rate or changes in gene expression. Several studies support the idea that diet can influence the risk of cancer; however information concerning the precise dietary factor that determines human cancer is an ongoing debate. A lot of epidemiological studies, involving food frequency questionnaires, have been developed providing important information concerning diet and cancer, however, diet is a complex composite of various nutrients (macro and micronutrients) and non-nutritive food constituents that makes the search for specific factors almost limitless.
Peer review: yes
URI: http://hdl.handle.net/10400.21/5055
DOI: 10.3389/conf.fgene.2015.01.00012
Versão do Editor: http://www.frontiersin.org/10.3389/conf.fgene.2015.01.00012/event_abstract
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