Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/5000
Título: Avoiding healthy cells extinction in a cancer model
Autor: Lopez, Álvaro G.
Sabuco, Juan
Seoane, Jesus M.
Duarte, Jorge das Neves
Januário, Cristina Isabel Caetano Ferreira
Sanjuan, Miguel A. F.
Palavras-chave: Cancer Models
Partial Control
Chaos
Tumor Growth
Therapy
Data: 21-Mai-2014
Editora: Academic Press LTD – Elsevier Science LTD
Citação: Álvaro G.; [et al] – Avoiding healthy cells extinction in a cancer model. Journal of Theoretical Biology. ISSN: 0022-5193. Vol. 349 (2014), pp. 74-81
Resumo: We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. For certain parameter choice, the dynamical system displays chaotic motion and by decreasing the response of the immune system to the tumor cells, a boundary crisis leading to transient chaotic dynamics is observed. This means that the system behaves chaotically for a finite amount of time until the unavoidable extinction of the healthy and immune cell populations occurs. Our main goal here is to apply a control method to avoid extinction. For that purpose, we apply the partial control method, which aims to control transient chaotic dynamics in the presence of external disturbances. As a result, we have succeeded to avoid the uncontrolled growth of tumor cells and the extinction of healthy tissue. The possibility of using this method compared to the frequently used therapies is discussed. (C) 2014 Elsevier Ltd. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.21/5000
DOI: 10.1016/j.jtbi.2014.01.040
ISSN: 0022-5193
1095-8541
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0022519314000599#
Aparece nas colecções:ISEL - Matemática - Artigos

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