Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/4951
Título: New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leucemia cancer cells
Autor: Valente, Andreia
Santos, Ana Margarida
Corte-Real, Leonor
Robalo, Maria Paula Alves
Moreno, Virtudes
Font-Bardia, Merce
Calvet, Teresa
Lorenzo, Julia
Garcia, Maria Helena
Palavras-chave: Iron(II)
Cyclopentadienyl
Atomic Force Microscopy (AFM)
Leukemia Cancer Cells
Apoptosis
Data: Abr-2014
Editora: Elsevier Science SA
Citação: VALENTE, Andreia; [et al] – New Iron(II) Cyclopentadienyl derivative complexes: Synthesis and antitumor activity against human leucemia cancer cells. Journal of Organometallic Chemistry. ISSN: 0022-328X. Vol. 756 (2104), pp. 52-60
Resumo: A new family of "Fe-II(eta(5)-C5H5)" half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UV-Vis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P2(1)/c and monoclinic P2(1)/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin. (C) 2014 Elsevier B.V. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.21/4951
DOI: 10.1016/j.jorganchem.2014.01.027
ISSN: 0022-328X
1872-8561
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos

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