Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/4934
Título: Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells
Autor: Sedlacek, Jindrich
Martins, Luísa Margarida D. R. S.
Danek, Petr
Pombeiro, Armando J. L.
Cvek, Boris
Palavras-chave: Disulfiram
Dietary Supplements
Dithiocarbamate-Metal Complexes
Cancer
Proteasome
Copper
Manganese
Data: Nov-2014
Editora: University South Bohemia
Citação: SEDLACEK, Jindrich; [et al] – Diethydithiocarbamate complexes with metals used as food suplements show diferente effects in cancer cells. Journal of Applied Biomedicine. ISSN: 1214-021X. Vol. 12, nr. 4 (2014), pp. 301-308
Resumo: Diethyldithiocarbamate (ditiocarb), a metabolite of the old anti-alcoholic drug disulfiram (Antabuse), forms proteasome-inhibiting metal complexes with copper or zinc that suppress cancer cells both in vitro and in vivo. The drug has been used in a clinical trial (NCT00742911) along with copper gluconate as a dietary supplement in patients with cancer spreading to the liver. In this study, we demonstrate the effect of synthetic complexes of disulfiram with four various metals (Mn, Fe, Cr and Cu) used as food supplements. These complexes may be spontaneously formed in the blood during the use of disulfiram with divalent metals and thus may suppress the growth of cancer in vivo. The cytotoxic effect of the compounds and the compounds' ability to inhibit the cellular proteasome were tested in the osteosarcoma cell line U2OS. After 48 h, copper and manganese complexes exhibited cytotoxic effect on the cell line, in sharp contrast to both iron and chromium complexes. (C) 2014 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.21/4934
DOI: 10.1016/j.jab.2014.04.002
ISSN: 1214-021X
1214-0287
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos

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