Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/4889
Título: Genotoxic assessment in different exposure groups working with antineoplastic agents
Autor: Ladeira, Carina
Viegas, Susana
Pádua, Mário
Carolino, Elisabete
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Occupational health
Genotoxic assessment
Antineoplastic drugs
Cytostatic drugs
Data: 2015
Editora: Taylor & Francis
Citação: Ladeira C, Viegas S, Pádua M, Carolino E, Gomes MC, Brito M. Genotoxic assessment in different exposure groups working with antineoplastic agents. In Arezes PM, Baptista JS, Barroso MP, Carneiro P, Cordeiro P, Costa N, et al, editors. Occupational safety and hygiene III. London: Taylor & Francis; 2015. p. 177-80.
Resumo: Antioneoplastic drugs are widely used in treatment of cancer, and several studies suggest acute and long-term effects associated to antineoplastic drug exposures, namely associating workplace exposure with health effects. Cytokinesis blocked micronucleus (CBMN) assay is one promising short-term genotoxicity assays for human risk assessment and their combination is recommended to monitor populations chronically exposed to genotoxic agents. The aim of this investigation is the genotoxicity assessment in different professionals that handle cytostatics drugs. This research is case-control blinded study constituted by 46 non-exposed subjects and 44 workers that handle antineoplastic drugs, such as pharmacists, pharmacy technicians, and nurses. It was found statistically significant increases in the genotoxicity biomarkers in exposed comparising with controls (p<0.05). The findings address the need for regular biomonitoring of personnel occupationally exposed to these drugs, confirming to an enhanced health risk assessment.
Peer review: yes
URI: http://hdl.handle.net/10400.21/4889
DOI: 10.1201/b18042-37
Versão do Editor: http://www.amazon.com/Occupational-Safety-Hygiene-Pedro-Arezes/dp/1138027650#reader_1138027650
Aparece nas colecções:ESTeSL - Capítulos ou partes de livros

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Genotoxic assessment in different exposure groups working with antineoplastic agents.pdf461,48 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.