Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/4881
Título: Insulin resistance does not play a major role in lipid and apolipoprotein profile in obese women
Autor: Silva-Nunes, José
Brito, Miguel
Veiga, Luísa
Palavras-chave: Insulin resistance
Lipide
Obesity
Women
Data: Mai-2015
Editora: BioScientifica
Citação: Silva-Nunes J, Brito M, Veiga L. Insulin resistance does not play a major role in lipid and apolipoprotein profile in obese women. IN ECE 2015, Dublin (Ireland), 16-20 May 2015. Endocr Abstr. 2015;37:EP643.
Resumo: Background: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR). Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in obese women. Methods: We studied 112 obese and 100 normal-weight premenopausal women without known cardiovascular disease. Both groups were characterized for anthropometrics and a fasting blood sample was collected for assessment of glucose, insulin, triglycerides, cholesterol (total, LDL and HDL), and apolipoproteins A-I, A-II, B, C-II, C-III, and E; IR was assessed by the homeostatic model assessment (HOMA-IR). We compared lipids between obese and lean women; we looked for correlation of those levels with anthropometrics and IR (independently from anthropometrics) in obese women. Results: Obese women were characterized by mean age=34.6±8.3 years, BMI=43.6±7.9 kg/m2, waist circumference (Wc)=117.5±15.1 cm, and HOMA-IR=4.28±3.5. Lean women (age=34.2±8.3 years, BMI=21.4±1.7 kg/m2, Wc=71.7±5.8 cm, and HOMA-IR=1.21±0.76) presented with significantly lower levels of total cholesterol (P=0.001), LDL-cholesterol (P<0.001), and triglycerides (P<0.001); they presented higher levels of HDL-cholesterol (P<0.001), Apo A-I (P<0.001) and Apo A-II (P=0.037). HOMA-IR showed no significant association with apolipoproteins. HOMA-IR was inversely associated with HDL-cholesterol (P=0.048; r=−0.187) but that association disappeared when we adjusted for waist circumference. Only triglycerides were directly associated with HOMA-IR (P<0.001; r=0.343) independently from anthropometrics. Conclusion: We confirm that obese women present worst lipid and apolipoprotein profile. However, with the exception for triglycerides, insulin resistance per se does not play a major role in lipid and apolipoprotein abnormalities observed in obese women.
Peer review: yes
URI: http://hdl.handle.net/10400.21/4881
DOI: 10.1530/endoabs.37.EP643
Versão do Editor: http://www.endocrine-abstracts.org/ea/0037/ea0037ep643.htm
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