Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3768
Título: Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory gd T cell subsets
Autor: Schmolka, Nina
Serre, Karine
Grosso, Ana R.
Rei, Margarida
Pennington, Daniel J.
Gomes, Anita Q.
Silva-Santos, Bruno
Palavras-chave: Cell differentiation
Cytokines
Gene expression profiling
Gene expression regulation
Methylation
T-Lymphocyte subsets
Th1 cells
Th17 cells
Transcriptome
Data: Set-2013
Editora: Nature
Citação: Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B. Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol. 2013;14(10):1093-100.
Resumo: Two distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to identify the regulatory networks of peripheral IFN-γ-producing or IL-17-producing γδ T cell subsets in vivo. We found that CD27(+) γδ T cells were committed to the expression of Ifng but not Il17, whereas CD27(-) γδ T cells displayed permissive chromatin configurations at loci encoding both cytokines and their regulatory transcription factors and differentiated into cells that produced both IL-17 and IFN-γ in a tumor microenvironment.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3768
DOI: 10.1038/ni.2702
Versão do Editor: http://www.immunology.kserre.net/docs/2013-Nature-Immunol-Epigenetic-on-gd-T-cells-.pdf
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