Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3364
Título: Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphism
Autor: Brito, Miguel
Ferreira, Paula
Guerreiro, Catarina Sousa
Malta-Vacas, Joana
Tavares, L.
Santos, P.
Pinto, A.
Cravo, Marília
Palavras-chave: Crohn disease
Ecosapentanoic acid
Genotypes
IL6 174 CC
Data: 2008
Editora: Elsevier
Citação: Brito M, Ferreira P, Guerreiro CS, Malta-Vacas J, Tavares L, Santos P, et al. Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphism. Clin Nutr Suppl. 2008;3 Suppl 1:53.
Resumo: Rationale: Omega 3 fatty acids have been shown to be of potential benefit in patients with CD. The aim of the present study was to evaluate whether EPA can modulate the inflammatory response according to different genotypes of IL6G174G/C polymorphism. Methods: Peripheral blood cells were collected from CD patients with different genotypes for IL6 174G/C (GG, n = 16, GC, n = 8, CC, n = 7), and lymphocytes were established in culture media. Replicates with the addition of EPA (25 mM) were analysed in a period of 24h, 48h and 72h. Expression of IL6 e a PGE2 was assessed by ELISA. Apoptosis and cellular proliferation was determined by flow cytometry.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3364
Versão do Editor: http://www.clinicalnutritionsupplements.com/article/S1744-1161%2808%2970119-4/abstract
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