Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3069
Título: Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex
Autor: Pala, Irene
Schartl, Manfred
Brito, Miguel
Malta-Vacas, Joana
Coelho, Maria Manuela
Palavras-chave: Biological evolution
Cyprinidae
DNA/genetics
Gene expression profiling
Gene expression regulation
Polyploidy
RNA/genetics
Data: Nov-2010
Editora: Royal Society Publishing
Citação: Pala I, Schartl M, Brito M, Malta Vacas J, Coelho MM. Gene expression regulation and lineage evolution: the North and South tale of the hybrid polyploid Squalius alburnoides complex. Proc Biol Sci. 2010;277(1699):3519-25.
Resumo: The evolution of hybrid polyploid vertebrates, their viability and their perpetuation over evolutionary time have always been questions of great interest. However, little is known about the impact of hybridization and polyploidization on the regulatory networks that guarantee the appropriate quantitative and qualitative gene expression programme. The Squalius alburnoides complex of hybrid fish is an attractive system to address these questions, as it includes a wide variety of diploid and polyploid forms, and intricate systems of genetic exchange. Through the study of genome-specific allele expression of seven housekeeping and tissue-specific genes, we found that a gene copy silencing mechanism of dosage compensation exists throughout the distribution range of the complex. Here we show that the allele-specific patterns of silencing vary within the complex, according to the geographical origin and the type of genome involved in the hybridization process. In southern populations, triploids of S. alburnoides show an overall tendency for silencing the allele from the minority genome, while northern population polyploids exhibit preferential biallelic gene expression patterns, irrespective of genomic composition. The present findings further suggest that gene copy silencing and variable expression of specific allele combinations may be important processes in vertebrate polyploid evolution.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3069
ISSN: 1471-2954
Versão do Editor: http://rspb.royalsocietypublishing.org/content/277/1699/3519.full.pdf+html
Aparece nas colecções:ESTeSL - Artigos

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