Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3050
Título: Risk factors for metabolic bone disease in Crohn's disease patients
Autor: Cravo, Marília
Guerreiro, Catarina Sousa
Santos, Paula Moura dos
Brito, Miguel
Ferreira, Paula
Fidalgo, Catarina
Tavares, Lourdes
Pereira, António Dias
Palavras-chave: Body composition
Body mass index
Bone density
Bone diseases
Case-control studies
Crohn disease
Interleukin-1
Interleukin-6
Risk factor
Tumor necrosis factor-alpha
Data: Dez-2010
Editora: Wiley
Citação: Cravo M, Guerreiro CS, dos Santos PM, Brito M, Ferreira P, Fidalgo C, et al. Risk factors for metabolic bone disease in Crohn's disease patients. Inflamm Bowel Dis. 2010;16(12):2117-24.
Resumo: Background: The aim was to evaluate the presence of metabolic bone disease (MBD) in patients with Crohn’s disease (CD) and to identify potential etiologic factors. Methods: The case–control study included 99 patients with CD and 56 controls with a similar age and gender distribution. Both groups had dual-energy x-ray absorptionmetry and a nutritional evaluation. Single nucleotide polymorphisms at the IL1, TNF-a, LTa, and IL-6 genes were analyzed in patients only. Statistical analysis was performed using SPSS software. Results: The prevalence of MBD was significantly higher in patients (P ¼ 0.006). CD patients with osteoporosis were older (P < 0.005), small bowel involvement and surgical resections were more frequent (P < 0.005), they more often exhibited a penetrating or stricturing phenotype (P < 0.05), duration of disease over 15 years (P < 0.005), and body mass index (BMI) under 18.5 kg/m2 (P < 0.01) were more often found. No association was found with steroid use. Patients with a Z-score < 2.0 more frequently had chronic active disease (P < 0.05). With regard to diet, low vitamin K intake was more frequent (P ¼ 0.03) and intake of total, monounsaturated, and polyunsaturated fat was higher in patients with Z-score < 2.0 (P < 0.05). With respect to genetics, carriage of the polymorphic allele for LTa252 A/G was associated with a higher risk of osteoporosis (P ¼ 0.02). Regression analysis showed that age over 40 years, chronic active disease, and previous colonic resections were independently associated with the risk of developing MBD. Conclusions: The prevalence of MBD was significantly higher in CD patients. Besides the usual risk factors, we observed that factors related to chronic active and long-lasting disease increased the risk of MBD.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3050
ISSN: 1536-4844
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/ibd.21297/pdf
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