Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3037
Título: Adaptive mutations in bacteria: high rate and small effects
Autor: Perfeito, Lília
Fernandes, Lisete
Mota, Catarina
Gordo, Isabel
Palavras-chave: Adaptation, Biological
Biological evolution
Escherichia coli/genetics
Escherichia coli/physiology
Genome, Bacterial
Microsatellite repeats
Mutation
Selection, Genetic
Data: Ago-2007
Editora: Science
Citação: Perfeito L, Fernandes L, Mota C, Gordo I. Adaptive mutations in bacteria: high rate and small effects. Science. 2007;317(5839):813-5.
Resumo: Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10–5 per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3037
ISSN: 1095-9203
Versão do Editor: http://www.sciencemag.org/content/317/5839/813.abstract
Aparece nas colecções:ESTeSL - Artigos

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