Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2882
Título: Synthesis, characterization, electrochemical behavior and in vitro protein tyrosine kinase inhibitory activity of the cymene-halogenobenzohydroxamato [Ru(eta(6)-cymene)(bha)Cl] complexes
Autor: Shang, Xianmei
Silva, Telma F. S.
Martins, Luísa Margarida D. R. S.
Li, Qingshan
Silva, M. Fatima C. Guedes da
Kuznetsov, Maxim L.
Pombeiro, Armando J. L.
Palavras-chave: Ruthenium(II) complexes
Synthesis
Protein tyrosine kinase inhibitor
Electrochemistry
Ruthenium(II) arene complexes
Anticancer agents
Coordination chemistry
Platinum complexes
X-ray
Ferrocene derivatives
Molecular-structure
Crystal-structures
Design strategies
Redox potentials
Data: 15-Abr-2013
Editora: Elsevier Science SA
Citação: SHANG, Xianmei; SILVA, Telma F. S.; MARTINS, Luisa M. D. R. S.; LI, Qingshan; SILVA, M. Fatima C. Guedes da; KUZNETSOV, Maxim L.; POMBEIRO, Armando J. L. - Synthesis, characterization, electrochemical behavior and in vitro protein tyrosine kinase inhibitory activity of the cymene-halogenobenzohydroxamato [Ru(eta(6)-cymene)(bha)Cl] complexes. Journal of Organometallic Chemistry. ISSN 0022-328X. Vol. 730 (2013), p. 137-143.
Resumo: The ruthenium(II)-cymene complexes [Ru(eta(6)-cymene)(bha)Cl] with substituted halogenobenzohydroxamato (bha) ligands (substituents = 4-F, 4-Cl, 4-Br, 2,4-F-2, 3,4-F-2, 2,5-F-2, 2,6-F-2) have been synthesized and characterized by elemental analysis, IR, H-1 NMR, C-13 NMR, cyclic voltammetry and controlled-potential electrolysis, and density functional theory (DFT) studies. The compositions of their frontier molecular orbitals (MOs) were established by DFT calculations, and the oxidation and reduction potentials are shown to follow the orders of the estimated vertical ionization potential and electron affinity, respectively. The electrochemical E-L Lever parameter is estimated for the first time for the various bha ligands, which can thus be ordered according to their electron-donor character. All complexes exhibit very strong protein tyrosine kinase (PTK) inhibitory activity, even much higher than that of genistein, the clinically used PTK inhibitory drug. The complex containing the 2,4-difluorobenzohydroxamato ligand is the most active one, and the dependences of the PTK activity of the complexes and of their redox potentials on the ring substituents are discussed. (C) 2012 Elsevier B.V. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2882
ISSN: 0022-328X
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos



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