Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2844
Título: Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies
Autor: Silva, Telma F. S.
Smolenski, Piotr
Martins, Luísa Margarida D. R. S.
Guedes da Silva, M. Fatima C.
Fernandes, Alexandra R.
Luis, Daniel
Silva, Ana
Santos, Susana
Borralho, Pedro M.
Rodrigues, Cecilia M. P.
Pombeiro, Armando J. L.
Palavras-chave: Cobalt
Zinc
N ligands
Medicinal chemistry
Antitumor agents
Transition-metal-complexes
In-vitro cytotoxicity
Ray crystal-structure
Water-soluble PTA
Coordination chemistry
Superoxide-dismutase
Anticancer activity
Ligands
1ST
Drugs
Data: Jul-2013
Editora: Wiley-V C H Verlag GMBH
Citação: SILVA, Telma F. S.; SMOLENSKI, Piotr; MARTINS, Luisa M. D. R. S.; GUEDES DA SILVA, M. Fatima C.; FERNANDES, Alexandra R.; LUIS, Daniel; SILVA Ana; SANTOS, Susana; BORRALHO, Pedro M.; RODRIGUES, Cecilia M. P.; POMBEIRO, Armando J. L. - Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies. European Journal of Inorganic Chemistry. ISSN 1434-1948. Vol. 2013, nr. 21 (2013), p. 3651-3658.
Resumo: The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)(2)][BF4] (2, DION = 1,10-phenanthroline-5,6-dione), [Zn(DION)(2)]Cl-2 (3) and [ZnCl(O-PTA=O)(DION)][BF4] (4) were synthesized by reaction of CoCl2 with [mPTA]I or DION and ZnCl2 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far-IR, H-1, C-13 and P-31{H-1} NMR spectroscopy, ESI-MS, elemental analyses and single-crystal X-ray diffraction structural analysis (for 1). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2844
ISSN: 1434-1948
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos



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