Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2774
Título: Association of FTO and PPARG polymorphisms with obesity in Portuguese women
Autor: Carlos, Fábio Ferreira
Silva-Nunes, José
Flores, Orfeu
Brito, Miguel
Doria, Gonçalo
Veiga, Luísa
Baptista, Pedro Viana
Palavras-chave: Obesity
Women
PPARG polymorphisms
FTO polymorphisms
rs9939609
rs1801282
BMI
SNP
Odds ratio
Portugal
Data: Jul-2013
Editora: Dove Press
Citação: Carlos FF, Silva-Nunes J, Flores O, Brito M, Doria G, Veiga L, Baptista PV. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. Diabetes Metab Syndr Obes. 2013;6:241-5.
Resumo: Purpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥30 g/m2, 99 controls with BMI 18.5–24.9 kg/m2) participated in this study. The association of the single-nucleotide polymorphisms with obesity was determined by odds ratio calculation with 95% confidence intervals. Results: Significant differences in allelic expression of FTO rs9939609 (P<0.05) were found between control and case groups, indicating a 2.5-higher risk for obesity in the presence of both risk alleles when comparing the control group with the entire obese group. A fourfold-higher risk was found for subjects with class III obesity compared to those with classes I and II. No significant differences in BMI were found between the control and case groups for PPARG rs1801282 (P>0.05). Conclusion: For the first time, a study involving an adult Portuguese population shows that individuals harboring both risk alleles in the FTO gene locus are at higher risk for obesity, which is in agreement to what has been reported for other European populations.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2774
ISSN: 1178-7007
Versão do Editor: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712741/
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