Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/275
Título: Body composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patients
Autor: Tomás, Mª Teresa
Santa-Clara, Helena
Monteiro, Estela
Baynard, Tracy
Carnero, Elvis
Bruno, Paula Marta
Barroso, Eduardo
Sardinha, Luís
Fernhall, Bo
Palavras-chave: Fisioterapia
Reabilitação
Polineuropatia amiloidótica familiar
Transplante de órgãos
Fígado
Incapacidade física
Six-minute Walk Test
Massa muscular
Data: Jul-2011
Editora: John Wiley & Sons
Citação: Tomás MT, Santa-Clara H, Monteiro E, Baynard T, Carnero E, Bruno PM, Barroso E, Sardinha L, Fernhall B. Body composition, muscle strength, functional capacity, and physical disability risk in liver transplanted familial amyloidotic polyneuropathy patients. Clin Transplant. 2011;25(4):E406-14.
Resumo: Abstract: Background: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease leading to sensory and motor polyneuropathies, and functional limitations. Liver transplantation is the only treatment for FAP, requiring medication that negatively affects bone and muscle metabolism. The aim of this study was to compare body composition, levels of specific strength, level of physical disability risk, and functional capacity of transplanted FAP patients (FAPTx) with a group of healthy individuals (CON). Methods: A group of patients with 48 FAPTx (28 men, 20 women) was compared with 24 CON individuals (14 men, 10 women). Body composition was assessed by dual-energy X-ray absorptiometry, and total skeletal muscle mass (TBSMM) and skeletal muscle index (SMI) were calculated. Handgrip strength was measured for both hands as was isometric strength of quadriceps. Muscle quality (MQ) was ascertained by the ratio of strength to muscle mass. Functional capacity was assessed by the six-minute walk test. Results: Patients with FAPTx had significantly lower functional capacity, weight, body mass index, total fat mass, TBSMM, SMI, lean mass, muscle strength, MQ, and bone mineral density. Conclusion: Patients with FAPTx appear to be at particularly high risk of functional disability, suggesting an important role for an early and appropriately designed rehabilitation program.
Peer review: yes
URI: http://hdl.handle.net/10400.21/275
ISSN: 1399-0012
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0012.2011.01436.x/abstract
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