Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2615
Título: Factors related with adiponectinemia in obese and normal-weight women and with its variation in weight loss programs
Autor: Silva-Nunes, José
Oliveira, Ana
Duarte, Leone
Barradas, Margarida
Melão, Alice
Brito, Miguel
Veiga, Luísa
Palavras-chave: Obesity
Adiponectin
Adipokines
Lifestyle factors
Weight loss
Bariatric surgery
Endocrinology
Data: Abr-2013
Editora: Karger
Citação: Silva-Nunes J, Oliveira A, Duarte L, Barradas M, Melão A, Brito M, Veiga L. Factors related with adiponectinemia in obese and normal-weight women and with its variation in weight loss programs. Obes Facts. 2013;6(2):124-33.
Resumo: Objective: To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgical/non-surgical interventions. Methods: We studied 100 normal-weight women and 112 obese premenopausal women; none of them was on any medical treatment. Women were characterized for anthropometrics, daily macronutrient intake, smoking status, contraceptives use, adiponectin as well as IL-6 and TNF-α serum concentrations. Results: Adiponectinemia was lower in obese women (p < 0.001), revealing an inverse association with waist-to-hip ratio (p < 0.001; r = –0.335). Normal-weight women presented lower adiponectinemia among smokers (p = 0.041); body fat, waist-to-hip ratio, TNF-α levels, carbohydrate intake, and smoking all influence adiponectinemia (r 2 = 0.436). After weight loss interventions, a significant modification in macronutrient intake occurs followed by anthropometrics decrease (chiefly after bariatric procedures) and adiponectinemia increase (similar after surgical and non-surgical interventions). After bariatric intervention, Δ adiponectinemia was inversely correlated to Δ waist circumference and Δ carbohydrate intake (r 2 = 0.706). Conclusion: Anthropometrics, diet, smoking, and TNF-α levels all influence adiponectinemia in normal-weight women, although explaining less than 50% of it. In obese women, anthropometrics modestly explain adiponectinemia. Opposite to non-surgical interventions, after bariatric surgery adiponectinemia increase is largely explained by diet composition and anthropometric changes.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2615
ISSN: 1662-4033
Versão do Editor: http://www.karger.com/Article/FullText/350664
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