Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/2250
Título: Syntheses, Molecular Structures, Electrochemical Behavior, Theoretical Study, and Antitumor Activities of Organotin(IV) Complexes Containing 1-(4-Chlorophenyl)-1-cyclopentanecarboxylato Ligands
Autor: Shang, Xianmei
Meng, Xianggao
Alegria, Elisabete Clara Bastos do Amaral
Li, Qingshan
Silva, M. Fátima C. Guedes da
Kuznetsov, Maxim L.
Pombeiro, Armando J. L.
Palavras-chave: Redox properties
Diorganotin(IV) complexes
Organometallic chemistry
Coordinatio-compounds
Anticancer complexes
Cancer-chemotherapy
Ruthenium complexes
Crystal-structures
Cell-growth
NMR-spectra
Data: 5-Set-2011
Editora: Amer Chemical SOC
Citação: SHANG, Xianmei; MENG, Xianggao; ALEGRIA, Elisabete C. B. A.; LI, Qingshan; GUEDES DA SILVA, M. Fátima C.; KUZNETSOV, Maxim L.; POMBEIRO, Armando J. L. - Syntheses, Molecular Structures, Electrochemical Behavior, Theoretical Study, and Antitumor Activities of Organotin(IV) Complexes Containing 1-(4-Chlorophenyl)-1-cyclopentanecarboxylato Ligands. Renewable Energy. ISSN 0020-1669. Vol. 50, n.º 17 (2011) p. 8158-8167.
Resumo: The organotin(IV) compounds [Me2Sn(L)(2)] (1), [Et(2)sn(L)(2)] (2), [(Bu2Sn)-Bu-n(L)(2)] (3), [(n)Oct(2)Sn(L)(2)] (4), [Ph2Sn(L)(2)] (5), and [PhOSnL](6) (6) have been synthesized from the reactions of 1-(4-chlorophenyl)-1-cyclopentanecarboxylic acid (HL) with the corresponding diorganotin(IV) oxide or dichloride. They were characterized by IR and multinuclear NMR spectroscopies, elemental analysis, cyclic voltammetry, and, for 2, 3, 4 and 6, single crystal X-ray diffraction analysis. While 1-5 are mononuclear diorganotin (IV) compounds, the X-ray diffraction of 6 discloses a hexameric drumlike structure with a prismatic Sn6O6 core. All these complexes undergo irreversible reductions and were screened for their in vitro antitumor activities toward HL-60, BGC-823, Bel-7402, and KB human cancer cell lines. Within the mononuclear compounds, the most active ones (3, 5) are easiest to reduce (least cathodic reduction potentials), while the least active ones (1, 4) are the most difficult to reduce. Structural rearrangements (i.e., Sn-O bond cleavages and trans-to-cis isomerization) induced by reduction, which eventually can favor the bioactivity, are disclosed by theoretical/electrochemical studies.
Peer review: yes
URI: http://hdl.handle.net/10400.21/2250
ISSN: 0020-1669
Aparece nas colecções:ISEL - Eng. Quim. Biol. - Artigos



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