Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/1994
Título: Stability of extemporaneously prepared captopril oral liquid formulation for paediatric patients
Autor: Caetano, Liliana Aranha
Gato, Sara
Almeida, T.
Cheong, F.
Graça, Anabela
Palavras-chave: Farmácia
Farmacologia
Captopril
Pediatria
Fórmula líquida
Data: Abr-2010
Editora: Escola Superior de Tecnologia da Saúde de Lisboa
Citação: Caetano LA, Gato S, Almeida T, Cheong F, Graça A. Stability of extemporaneously prepared captopril oral liquid formulation for paediatric patients. In Congresso Internacional das Ciências e Tecnologias da Saúde, Ilha Terceira (Acores), 29 de Abril-1 de Maio. Poster.
Resumo: Captopril, an inhibitor of angiotensin converting enzyme (ACE), is used to treat medical conditions like hypertension and heart failure, and it is usually administered in tablet form for adults. Since this dosage form is not recommended for infants and children up to 6 years, hospital pharmacies have to prepare liquid formulations for oral administration of captopril. Traditionally, concentration of captopril used in the formulations is 1mg/ml. The problem is that captopril is prone to oxidation, and its stability in solution is affected by pH, concentration of captopril, the presence of oxygen or metal ions. The influence of different formulation ingredients on the properties of physical and chemical stability of captopril in liquid preparations has been evaluated. Main of the study: to evaluate the stability of captopril for 30 days when formulated in a 1 mg/ml suspension adjuvanted with citric acid.
Peer review: yes
URI: http://hdl.handle.net/10400.21/1994
Aparece nas colecções:ESTeSL - Posters

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