Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/1503
Título: Genotoxicity biomarkers: application in histopathology laboratories
Autor: Ladeira, Carina
Viegas, Susana
Carolino, Elisabete
Gomes, Manuel Carmo
Brito, Miguel
Palavras-chave: Oncologia
Marcador tumoral
Incidência
Biologia molecular
Oncology
Tumoral marker
Incidence
Molecular biology
Data: Abr-2012
Editora: InTech
Citação: Ladeira C, Viegas S, Carolino E, Gomes MC, Brito M. Genotoxicity biomarkers: application in histopathology laboratories. In Khan TK, editor. Biomarker. InTech; 2012. p. 133-54.
Resumo: Most cancers results from man-made and natural environmental exposures (such as tobacco smoke; chemical pollutants in air, water, food, drugs; radon; and infectious agents) acting in concert with both genetic and acquired characteristics. It has been estimated that without these environmental factors, cancer incidence would be dramatically reduced, by as much as 80%-90%. The modulation of environmental factors by host susceptibility was rarely evaluated. However, within the past few years, the interaction between environmental factors and host susceptibility factors has become a very active area of research. Molecular biology as a tool for use in epidemiological studies has significant potential in strengthening the identification of cancers associated with environmental exposures related to lifestyle, occupation, or ambient pollution. In molecular epidemiology, laboratory methods are employed to document the molecular basis and preclinical effects of environmental carcinogenesis. Molecular epidemiology has become a major field of research and considerable progress has been made in validation and application of biomarkers and its greatest contribution has been the insights provided into interindividual variation in human cancer risk and the complex interactions between environmental factors and host susceptibility factors, both inherited and acquired, in the multistage process of carcinogenesis.
Peer review: yes
URI: http://hdl.handle.net/10400.21/1503
ISBN: 978-953-51-0577-0
Versão do Editor: http://www.intechopen.com/books/biomarker/genotoxicity-biomarkers-application-in-histopathology-laboratories
Aparece nas colecções:ESTeSL - Capítulos ou partes de livros

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